Most drugs used in clinical practice in the form of various pharmaceutical (dosage) forms - tablets, capsules, suppository and etc. depending on the forms of drugs have different bioavailability that should be taken into consideration when using drugs with therapeutic and preventive purpose.
After his release from dosage forms drug in molecular form of the current supplied to biofisa. This process europe steroids is preceded by the dissolution of the drug in biological fluids (gastric, intestinal juice when enteral introduction). The dissolved substance diffuses to the site of absorption, i.e. to membranes of epithelial cells of the mucous membrane of the stomach, intestines, mouth, alveolocytes, epithelium of the nasal part of the pharynx, conjunctiva, etc.
Medicines in the form of dosage forms you can enter into the body enteral and parenteral routes. To sterelny routes of administration of drugs include: oral (most common), sublingual and rectal. When enteral introduction resorptive pharmacological action is preceded by biotech steroids the processes of absorption of drug released from the dosage form, through epithelial cells of the mucous membrane of the digestive apparatus into the blood supply and further distribution in the body.
For parenteral routes of administration of drugs include: injections (subcutaneous, intramuscular, intravenous, intra-arterial, endolymphatic, zubarah-nodeline, intraosseous), of inhalation, of an application (cutaneous) and intracavitary path. If the drug is injected directly into the bloodstream (intravascular), under the absorption in a pharmacokinetic sense, it is clear the penetration of the drug to areas of the pharmacodynamic action (cell receptor) across the blood-tissue barriers.
Thus, it should be remembered that when any of the introduction of the drug has to penetrate through various biological membranes epithelial and endothelial cells.
The distribution of the current component of the drug in biological fluids, organs and tissues largely depends on the absorption and on the ability of drugs to penetrate biological of anabolics com contact-the wounds inside the tissues, cells and subcellular structures. Great importance is the ability of some drugs to dissolve in lipids; this creates significant tissue depots of injected drugs, develop cumulative effects. Besides Lee-popilnya substances are the only drugs easily penetrates through the cell membrane inside the cell without requiring energy input.